Gene News and Research

Latest Gene News and Research

Study could pave the way for synergistic therapeutic combinations to better treat SF3B1-mutant MDS

A new study from researchers with Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine and collaborating organizations provides insight into the underlying mechanisms of gene mutations commonly seen in patients with myelodysplastic syndromes (MDS) and other myeloid neoplasms.

11 Dec 2023

Targeted therapy reduces markers of disease burden, improves symptoms for patients with nonadvanced system mastocytosis

The targeted therapy bezuclastinib was safe and rapidly reduced markers of disease burden while also improving symptoms for patients with a rare blood disorder called nonadvanced system mastocytosis, according to results of the Phase II SUMMIT trial reported by researchers at The University of Texas MD Anderson Cancer Center.

11 Dec 2023

New atlas characterizes cellular landscape of the early human limb

Human fingers and toes do not grow outward; instead, they form from within a larger foundational bud, as intervening cells recede to reveal the digits beneath. This is among many processes captured for the first time as scientists unveil a spatial cell atlas of the entire developing human limb, resolved in space and time.

11 Dec 2023

New map offers valuable insights into the underlying mechanisms of neurodevelopmental disorders and cancer

Scientists have created the first extensive map showing how all possible genetic changes can affect health in the gene DDX3X, leading to valuable insights into the underlying mechanisms of neurodevelopmental disorders and cancer.

11 Dec 2023

Small molecule applications of process Raman spectroscopy

In this interview, Kevin Broadbelt of Thermo Fisher Scientific discusses the small molecule applications of process Raman spectroscopy.

From Thermo Fisher Scientific – Pharmaceutical and Biopharmaceutical Solutions 11 Dec 2023

Breakthrough in pancreatic cancer treatment: Inhibiting specific enzymes slows tumor progression

Study demonstrates that inhibiting stromal class I histone deacetylases (HDACs) can effectively slow down pancreatic cancer progression, shedding light on a new therapeutic approach targeting the tumor microenvironment.

10 Dec 2023

Low-risk DCIS patients may safely skip radiotherapy after surgery, study finds

Patients with low-risk ductal carcinoma in situ (DCIS) who skipped adjuvant radiotherapy after breast-conserving surgery had comparable five-year outcomes to those with high-risk DCIS who received adjuvant radiotherapy, according to results from the E4112 clinical trial presented at the San Antonio Breast Cancer Symposium, held December 5-9, 2023.

8 Dec 2023

Study identifies targetable fusion RNAs in breast cancer

Comprehensive profiling of fusion RNAs present in a large cohort of metastatic breast tumors revealed unique fusion mutations that may be therapeutically targetable, according to results presented at the San Antonio Breast Cancer Symposium, held December 5-9, 2023.

8 Dec 2023

Study offers new hope for heart repair and regeneration with reduced mitochondrial activity

USF Health Heart Institute doctors are upbeat about cardiac regeneration. But when those batteries – heart muscle cells called cardiomyocytes − short circuit and die, the damage can be devastating.

8 Dec 2023

Many patients may not benefit from gene-editing treatments for sickle cell disease

Federal approval of a breakthrough gene-editing technology that treats the pain and debilitating effects of sickle cell disease is cause for celebration among a community with few options for relief.

8 Dec 2023

Study sheds light on the molecular workings at play when oxygen exceeds normal levels

It only takes holding your breath for slightly too long to understand that too little oxygen is bad for you. But can you also have too much? Indeed, breathing air with a higher oxygen level than your body needs can cause health problems or even death.

8 Dec 2023

Scientists decode key factor in T cell lymphoma growth, paving way for new treatments

A team from the Technical University of Munich (TUM) has decoded the factor that makes T cell lymphomas grow comparatively rapidly: A missing "emergency shut-off switch" results in the lymphomas processing particularly large amounts of sugar and triggers other processes as well.

8 Dec 2023

Key gene linked to male bias in autism, Tourette's, and ADHD uncovered

Sex bias in attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and Tourette syndrome (TS).

8 Dec 2023

Groundbreaking 'Gnocchi' map reveals hidden secrets of the human genome

Study presents a genome-wide map, "Gnocchi," constructed from 76,156 human genomes, revealing that non-coding regions rich in regulatory elements are crucial in understanding human traits and diseases.

7 Dec 2023

Is your body out of sync? Study finds organs age at varying rates

Research uncovers that human organs age at varying rates, with some showing accelerated aging compared to chronological age, significantly impacting overall health and disease risk. The study used advanced blood plasma proteomics to analyze organ-specific aging in nearly 5,700 adults, linking it to increased risks of heart failure and Alzheimer's disease.

7 Dec 2023

Flaxseed lignans found to influence gut microbiome and breast cancer risk

A new study demonstrates that the human gut microbiome may be a factor in breast health. Lifestyle and diet have long been known to affect human health.

7 Dec 2023

Liver trigger holds the key to boosting gene therapy success

Indiana University School of Medicine researchers have uncovered vital insights regarding a liver trigger that blocks an undesired immune response from gene therapy, surprisingly resulting in the activation of specific immune cells, despite the liver's typical role in suppressing immune responses.

7 Dec 2023

Gene News and Research

Latest Gene News and Research

Study could pave the way for synergistic therapeutic combinations to better treat SF3B1-mutant MDS

Targeted therapy reduces markers of disease burden, improves symptoms for patients with nonadvanced system mastocytosis

New atlas characterizes cellular landscape of the early human limb

New map offers valuable insights into the underlying mechanisms of neurodevelopmental disorders and cancer

Small molecule applications of process Raman spectroscopy

Breakthrough in pancreatic cancer treatment: Inhibiting specific enzymes slows tumor progression

Low-risk DCIS patients may safely skip radiotherapy after surgery, study finds

Study identifies targetable fusion RNAs in breast cancer

Study offers new hope for heart repair and regeneration with reduced mitochondrial activity

Many patients may not benefit from gene-editing treatments for sickle cell disease

Study sheds light on the molecular workings at play when oxygen exceeds normal levels

Scientists decode key factor in T cell lymphoma growth, paving way for new treatments

Key gene linked to male bias in autism, Tourette's, and ADHD uncovered

Groundbreaking 'Gnocchi' map reveals hidden secrets of the human genome

Is your body out of sync? Study finds organs age at varying rates

Flaxseed lignans found to influence gut microbiome and breast cancer risk

Liver trigger holds the key to boosting gene therapy success

Researchers discover how bexmarilimab activates immune cells against tumors

Novel mechanism leads to motor neuron degeneration in spinal muscular atrophy

Breakthrough discovery paves the way for new methods to detect and treat leukemia

eBook: Using iPSCs models for human disease research and drug discovery eBook

PhD researcher at LifeArc

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

How GLP‑1 Agonists Are Shaping the Future of Obesity Treatment With Dr Bryony Henderson