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Multi-omics approach identifies potential drug combinations for AML treatment

Acute myeloid leukaemia (AML) is mainly characterized by an increase in the number of myeloid cells in the bone marrow and a decrease in mature cells, accounting for 28% of leukaemia cases, with a five-year survival rate of only 30.5%.

23 Jan 2025

New discovery sheds light on how bacteria use plasmids to build resistance

An international collaboration has achieved an important breakthrough in understanding the genetic mechanisms that allow bacteria to build resistance to drugs.

23 Jan 2025

Researchers identify ferroptosis as driver of osteocyte death in melanoma metastasis

Melanoma, one of the most aggressive forms of skin cancer, often metastasizes to bones, causing severe bone loss, an increased risk of fractures, and significant pain.

23 Jan 2025

School-based program cuts depression and anxiety in newcomer students

The first randomized control trial of the school-based intervention called Supporting Transition Resilience of Newcomer Groups (STRONG) shows significant reductions in depression, anxiety and behavior problems among refugee and immigrant students.

23 Jan 2025

Uncertainty surrounds effects of puberty blockers and hormone therapy for gender dysphoria

Major uncertainties remain about the impact of puberty blockers and gender affirming hormone therapy on children and young people with gender related distress (gender dysphoria), making it impossible to determine conclusively whether they help or harm, find two pooled data analyses of the available evidence, published online in the Archives of Disease in Childhood.

23 Jan 2025

Study finds link between impairments in physical function and hospital readmission risk

Researchers from The Ohio State University Wexner Medical Center and College of Medicine's School of Health and Rehabilitation Sciences (HRS) recently published a study that found a link between impairments in physical function and hospital readmission risk among adults 50 years of age and older.

23 Jan 2025

USF study: Pulmonary fibrosis after COVID-19 tends to get better

Pulmonary fibrosis is a rare, chronic disease that causes scarring in the lungs, making breathing difficult for people who suffer with it.

23 Jan 2025

Understanding the long-term effects of repetitive head hits in athletes

The impact makes us cringe-the sound of two helmets making contact during a football game, a player down on the field.

23 Jan 2025

Adverse childhood experiences linked to defensive gun use in adulthood

Researchers at Rutgers University have found that adverse childhood experiences can make people more sensitive to potential threats from others, which in turn increases their risk of engaging in defensive gun use in adulthood.

23 Jan 2025

New $20 million NIH grant aims to uncover the secrets of the human virome

Unlocking knowledge about the vast and varied collection of viruses that live in and on our bodies is the goal of a $20 million grant from the Common Fund of the National Institutes of Health (NIH) to researchers, including a team at UTHealth Houston.

23 Jan 2025

Parental divorce in childhood tied to 61% higher stroke risk in older adults

Experiencing parental divorce in childhood is associated with a significantly higher risk of stroke in older adulthood, even after accounting for key risk factors such as income, depression, and diabetes.

23 Jan 2025

Crick researchers identify key Y chromosome genes influencing sperm development

Researchers at the Crick have uncovered which genes on the Y chromosome regulate the development of sperm and impact fertility in male mice.

23 Jan 2025

Boosting BCL6 may counteract muscle loss from GLP-1 medications

About one in eight adults in the United States has tried or currently uses a GLP-1 medication, and a quarter of those users cite weight loss as their main goal.

23 Jan 2025

New approach to treating ependymoma with leukemia drug

Rakesh Jain PhD, Director of the E.L. Steele Laboratories for Tumor Biology at Massachusetts General Hospital and A. Werk Cook Professor of Radiation Oncology at Harvard Medical School, is senior author of a new study in PNAS, Targeting EPHB2/ABL1 Restores Anti-Tumor Immunity in Preclinical Models of Ependymoma.

23 Jan 2025

Research shows sharp growth in sedative and anxiety medication use disorders in youth

The prevalence of diagnosed disorders from recurrent use of sedative, hypnotic and antianxiety medications in adolescents and young adults has increased sharply since 2001, according to Rutgers Health researchers.

23 Jan 2025

Microplastics in the bloodstream may pose hidden risks to brain health

Trapped immune cells laden with microplastics starve the brain of oxygen—mouse study links vascular blockages to memory loss and motor deficits, with lingering risks even after symptoms fade.

23 Jan 2025

Two-thirds of people with post-COVID-19 syndrome experience long-term effects

Two-thirds of people with post-COVID-19 syndrome have persistent, objective symptoms – including reduced physical exercise capacity and reduced cognitive test performances – for a year or more, with no major changes in symptom clusters during the second year of their illness, according to a new study published January 23rd in the open-access journal PLOS Medicine by Winfried Kern of Freiburg University, Germany, and colleagues.

23 Jan 2025